The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms

Q Huang, J Mo, Z Liao, X Chen, B Zhang - Cell Death & Disease, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is a widely investigated RNA modification in studies on
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …

The RNA m6A writer METTL14 in cancers: Roles, structures, and applications

H Zhou, K Yin, Y Zhang, J Tian, S Wang - Biochimica et Biophysica Acta …, 2021 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is the most abundant and diverse epigenetic
modification of mRNAs in eukaryotes, and it regulates biological metabolism, cell …

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

XL Ping, BF Sun, LU Wang, W Xiao, X Yang, WJ Wang… - Cell research, 2014 - nature.com
Abstract The methyltransferase like 3 (METTL3)-containing methyltransferase complex
catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; …

The potential role of RNA N6-methyladenosine in Cancer progression

T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …

RNA N6-methyladenosine modification in cancers: current status and perspectives

X Deng, R Su, H Weng, H Huang, Z Li, J Chen - Cell research, 2018 - nature.com
Abstract N 6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …

A birds'‐eye view of the activity and specificity of the mRNA m6A methyltransferase complex

D Garcias Morales, JL Reyes - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Appropriate control of the transcriptome is essential to regulate different aspects of gene
expression during development and in response to environmental stimuli. Fast accumulating …

The role of m6A RNA methylation in human cancer

XY Chen, J Zhang, JS Zhu - Molecular cancer, 2019 - Springer
Abstract N 6-methyladenosine (m 6 A) is identified as the most common, abundant and
conserved internal transcriptional modification, especially within eukaryotic messenger …

Human m6A writers: Two subunits, 2 roles

X Wang, J Huang, T Zou, P Yin - RNA biology, 2017 - Taylor & Francis
Cellular RNAs with diverse chemical modifications have been observed, and N 6-
methyladenosine (m6A) is one of the most abundant internal modifications found on mRNA …

The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

[HTML][HTML] Function and evolution of RNA N6-methyladenosine modification

ZM Zhu, FC Huo, DS Pei - International journal of biological …, 2020 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m 6 A) is identified as the most prevalent and abundant
internal RNA modification, especially within eukaryotic mRNAs, which has attracted much …