Transcriptional silencing by CpG island methylation is a prevalent mechanism of tumor-
suppressor gene suppression in cancers 1, 2, 3, 4. Genetic experiments have defined the …

The role of the primary mammalian DNA methyltransferase, DNMT1, in maintaining CpG
island methylation in human colon cancer cells has recently been questioned. This …

Hypermethylation is associated with the silencing of tumour susceptibility genes in several
forms of cancer,; however, the mechanisms responsible for this aberrant methylation are …

Studies have shown that DNA (cytosine-5-)-methyltransferase 1 (DNMT1) is the principal
enzyme responsible for maintaining CpG methylation and is required for embryonic …

DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is
responsible for maintaining the DNA methylation pattern during cell division. A long list of …

Alterations in cytosine methylation patterns are usually observed in human tumors. The
consequences of altered cytosine methylation patterns include both inappropriate activation …

A major obstacle toward understanding how patterns of abnormal mammalian cytosine DNA
methylation are established is the difficulty in quantitating the de novo methylation activities …

Inactivation of tumour suppressor genes is central to the development of all common forms
of human cancer 1. This inactivation often results from epigenetic silencing associated with …

Hypermethylation associated silencing of the CpG islands of tumor suppressor genes is a
common hallmark of human cancer. Here we report a functional search for hypermethylated …

Abnormal methylation and associated silencing of tumor suppressor genes is a common
feature of many types of cancers. The observation of persistent methylation in human cancer …