B-cell Receptor (BCR) signalling plays a critical role in the progression of Chronic
Lymphocytic Leukaemia (CLL) and BCR-targeted kinase inhibitors, such as ibrutinib and …

Background: CLL cell trafficking is fundamental to CLL progression and an important focus
when identifying novel therapeutic targets. Toll-like receptor 9 (TLR9) is an intracellular …

Chronic lymphocytic leukemia (CLL) remains incurable despite B-cell receptor–targeted
inhibitors revolutionizing treatment. This suggests that other signaling molecules are …

Weak immunogenicity of chronic lymphocytic leukemia (CLL) cells may contribute to disease
progression and inhibit effective immunotherapy. Accordingly, agents that enhance the …

Chronic lymphocytic leukemia (CLL) is the most prevalent human leukemia and is
characterized by the progressive accumulation of long-lived malignant B cells. Here we …

Chronic lymphocytic leukemia (CLL) is a prototypic neoplasia in which malignant cells
strongly depend on microenvironmental stimulations in the lymphoid tissues where they …

Chronic lymphocytic leukemia (CLL) cells rely on signals from the microenvironment to for
cell activation, proliferation and survival. Microarray analysis of CLL cells harvested from …

Chronic lymphocytic leukemia cells strongly depend on external stimuli for their survival.
Both antigen receptor and co-stimulatory receptors, including Toll-like receptors, can …

There is strong evidence implicating microenvironmental sensors, including toll-like
receptors (TLRs), in the pathobiology of chronic lymphocytic leukaemia (CLL). 1, 2 We have …

Chronic lymphocytic leukaemia (CLL) cells are strongly influenced by microenvironmental
signals through the activation of distinct membrane receptors including the B‐cell receptor …