Human endogenous retroviruses (HERVs) are transposable genomic elements generally
repressed through DNA methylation. HERVs can be demethylated and expressed in …

Objective: Asthma is a common chronic childhood disease worldwide. Socioeconomic
status, genetic predisposition and environmental factors contribute to its incidence and …

Human rhinovirus infection (HRVI) plays an important role in asthma exacerbations and is
thought to be involved in asthma development during early childhood. We hypothesized that …

Background Epigenetic marks are heritable, influenced by the environment, direct the
maturation of T lymphocytes, and in mice enhance the development of allergic airway …

Epigenome-wide studies of methylation in children support a role for epigenetic
mechanisms in asthma; however, studies in adults are rare and few have examined non …

Background Genetic susceptibility and environmental influences are important contributors
to the development of asthma and atopic diseases. Epigenetic mechanisms may facilitate …

Rationale: Exposure to particulate air pollution has been related to increased hospitalization
and death, particularly from cardiovascular disease. Lower blood DNA methylation content …

Background Respiratory syncytial virus (RSV) infection has been associated with childhood
wheeze and asthma, and potential mechanisms include persistent epigenetic effects …

Background Beta‐2 adrenergic receptor (ADRB 2) is the primary target of both short‐and
long‐acting beta‐agonist asthma medications. ADRB 2 5′‐UTR methylation changes in …

Background Asthma is an increasingly common chronic disease among children, and data
point toward a complex mechanism involving genetic, environmental and epigenetic factors …