Transposable elements shape the evolution of mammalian development
AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Transposable elements in the mammalian embryo: pioneers surviving through stealth and service
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary
time, TE insertions can supply new promoter, enhancer, and insulator elements to protein …
time, TE insertions can supply new promoter, enhancer, and insulator elements to protein …
[PDF][PDF] Hominoid-specific transposable elements and KZFPs facilitate human embryonic genome activation and control transcription in naive human ESCs
Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene
expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling …
expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling …
Primate-specific transposable elements shape transcriptional networks during human development
The human genome contains more than 4.5 million inserts derived from transposable
elements (TEs), the result of recurrent waves of invasion and internal propagation …
elements (TEs), the result of recurrent waves of invasion and internal propagation …
Transposable elements as genetic regulatory substrates in early development
WD Gifford, SL Pfaff, TS Macfarlan - Trends in cell biology, 2013 - cell.com
The abundance and ancient origins of transposable elements (TEs) in eukaryotic genomes
has spawned research into the potential symbiotic relationship between these elements and …
has spawned research into the potential symbiotic relationship between these elements and …
The impact of transposable elements on mammalian development
JL Garcia-Perez, TJ Widmann, IR Adams - Development, 2016 - journals.biologists.com
Despite often being classified as selfish or junk DNA, transposable elements (TEs) are a
group of abundant genetic sequences that have a significant impact on mammalian …
group of abundant genetic sequences that have a significant impact on mammalian …
Nimble and ready to mingle: transposon outbursts of early development
D Rodriguez-Terrones, ME Torres-Padilla - Trends in Genetics, 2018 - cell.com
Transposable elements are the largest individual constituent of mammalian genomes.
These elements are highly diverse, a consequence of the multiplicity of genomic habitats …
These elements are highly diverse, a consequence of the multiplicity of genomic habitats …
[PDF][PDF] Transposable elements and their KRAB-ZFP controllers regulate gene expression in adult tissues
KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of
transposable elements (TEs), which they repress with their cofactor KAP1 through histone …
transposable elements (TEs), which they repress with their cofactor KAP1 through histone …
Evolutionally dynamic L1 regulation in embryonic stem cells
N Castro-Diaz, G Ecco, A Coluccio… - Genes & …, 2014 - genesdev.cshlp.org
Mobile elements are important evolutionary forces that challenge genomic integrity. Long
interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still …
interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still …
Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes
V Sundaram, J Wysocka - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …
within the vast non-coding genomic space and recognized by the transcription factors in a …
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