Transposable elements shape the evolution of mammalian development

AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Transposable elements in the mammalian embryo: pioneers surviving through stealth and service

P Gerdes, SR Richardson, DL Mager, GJ Faulkner - Genome biology, 2016 - Springer
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary
time, TE insertions can supply new promoter, enhancer, and insulator elements to protein …

[PDF][PDF] Hominoid-specific transposable elements and KZFPs facilitate human embryonic genome activation and control transcription in naive human ESCs

J Pontis, E Planet, S Offner, P Turelli, J Duc, A Coudray… - Cell stem cell, 2019 - cell.com
Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene
expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling …

Primate-specific transposable elements shape transcriptional networks during human development

J Pontis, C Pulver, CJ Playfoot, E Planet, D Grun… - Nature …, 2022 - nature.com
The human genome contains more than 4.5 million inserts derived from transposable
elements (TEs), the result of recurrent waves of invasion and internal propagation …

Transposable elements as genetic regulatory substrates in early development

WD Gifford, SL Pfaff, TS Macfarlan - Trends in cell biology, 2013 - cell.com
The abundance and ancient origins of transposable elements (TEs) in eukaryotic genomes
has spawned research into the potential symbiotic relationship between these elements and …

The impact of transposable elements on mammalian development

JL Garcia-Perez, TJ Widmann, IR Adams - Development, 2016 - journals.biologists.com
Despite often being classified as selfish or junk DNA, transposable elements (TEs) are a
group of abundant genetic sequences that have a significant impact on mammalian …

Nimble and ready to mingle: transposon outbursts of early development

D Rodriguez-Terrones, ME Torres-Padilla - Trends in Genetics, 2018 - cell.com
Transposable elements are the largest individual constituent of mammalian genomes.
These elements are highly diverse, a consequence of the multiplicity of genomic habitats …

[PDF][PDF] Transposable elements and their KRAB-ZFP controllers regulate gene expression in adult tissues

G Ecco, M Cassano, A Kauzlaric, J Duc, A Coluccio… - Developmental cell, 2016 - cell.com
KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of
transposable elements (TEs), which they repress with their cofactor KAP1 through histone …

Evolutionally dynamic L1 regulation in embryonic stem cells

N Castro-Diaz, G Ecco, A Coluccio… - Genes & …, 2014 - genesdev.cshlp.org
Mobile elements are important evolutionary forces that challenge genomic integrity. Long
interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still …

Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes

V Sundaram, J Wysocka - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …