The complement system, an essential part of the innate immune system, is composed of a
group of secreted and membrane proteins that collectively participate in maintaining the …

Recent discoveries implicate the classical complement cascade in normal brain
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …

Complement is an important component of the innate immune response with the capacity to
recognize and clear infectious challenges that invade the CNS through a damaged blood …

The complement cascade is an important arm of the immune system that plays a key role in
protecting the central nervous system (CNS) from infection. Recently, it has also become …

The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …

Acute neurodegeneration is associated with high morbidity and mortality, and there are few
effective treatments. Inflammation is central to the process of neuronal death, yet the roles of …

The immune response after brain injury is highly complex and involves both local and
systemic events at the cellular and molecular level. It is associated to a dramatic over …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

The complement system is an assembly of proteins that collectively participate in the
functions of the healthy and diseased brain. The complement system plays an important role …

The complement cascade has long been recognized to play a key role in inflammatory and
degenerative diseases. It is a 'double edged'sword as it is necessary to maintain health, yet …