Germ cell development creates totipotency through genetic as well as epigenetic regulation
of the genome function. Primordial germ cells (PGCs) are the first germ cell population …

Primordial germ cells (PGCs) are the embryonic precursors of the gametes and represent
the founder cells of the germline. Specification of PGCs is a critical divergent point during …

Primordial germ cells (PGCs) are the precursors of sperm and eggs, which generate a new
organism that is capable of creating endless new generations through germ cells. PGCs are …

Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving
rise to the next generation in mammals and many other multicellular organisms. How germ …

Mammalian primordial germ cells (PGCs) are induced in the embryonic epiblast, before
migrating to the nascent gonads. In fish, frogs, and birds, the germline segregates even …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …

In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from
pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) …

The expansion of primordial germ cells (PGC s), the precursors for the oocytes and
spermatozoa, is a key challenge in reproductive biology/medicine. Using a chemical …

The specification of germ cell fate in development initiates mechanisms essential for the
perpetuation of genetic information across the generations. Recent studies in mice have …