Background: Large-scale human and mechanistic mouse studies indicate a strong
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …

Trimethylamine N-oxide (TMAO) is a biologically active molecule generated by the gut
microbiota. Accumulating evidences have indicated a close association between high …

Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …

Summary Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite,
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …

Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Aims Gut microbiota-derived metabolite trimethylamine-N-oxide (TMAO) is emerging as a
new potentially important cause of increased cardiovascular risk. The purpose of this meta …

Aging is associated with stiffening of the large elastic arteries and consequent increases in
systolic blood pressure (SBP), which together increase cardiovascular disease risk; …

The increasing prevalence of cardiovascular diseases cannot adequately be explained by
traditional risk factors. Recently, accumulating evidence has suggested that gut microbiota …

Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet,
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …

There is increasing appreciation that changes in microbiome composition and function can
promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites …