We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …

Abstract DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA
methyltransferase activity but regulates de novo DNA methylation. While biochemical …

DNA methylation is essential for development. Two DNA methyltransferases, Dnmt3a and
Dnmt3b, contribute to the creation of DNA methylation patterns in embryos. We …

Maintenance of genomic methylation patterns in mammalian somatic cells depends on DNA
methyltransferase-1 (Dnmt1). Mouse oocytes and preimplantation embryos lack Dnmt1 but …

Several organisms have retained methyltransferase 2 (Dnmt2) as their only candidate DNA
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …

The imprinting of mammalian genes depends on the maintenance of DNA methylation
patterns during pre-and postimplantation development. Dnmt1o is a variant form of the …

DNA methylation is one of the epigenetic mechanisms and plays important roles during
oogenesis and early embryo development in mammals. DNA methylation is basically known …

Methylation of DNA is involved in tissue-specific gene control, and establishment of DNA
methylation pattern in the genome is thought to be essential for embryonic development …

The establishment of DNA methylation patterns requires de novo methylation that occurs
predominantly during early development and gametogenesis in mice. Here we demonstrate …

De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B.
Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) …