Cytosine methylation is an epigenetic modification of DNA catalyzed by DNA
methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have …

Amyotrophic lateral sclerosis (ALS) is the third most common adult-onset neurodegenerative
disease. A diagnosis is fatal owing to degeneration of motor neurons in brain and spinal …

DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA
methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene …

DNA methylation is an epigenetic mechanism involved in gene regulation and implicated in
the functioning of the nervous system. The de novo DNA methyltransferase Dnmt3a is …

Mitochondrial DNA (mtDNA) has been reported to contain 5-methylcytosine (5mC) at CpG
dinucleotides, as in the nuclear genome, but neither the mechanism generating mtDNA …

Autosomal dominant cerebellar ataxia-deafness and narcolepsy (ADCA-DN) and Hereditary
sensory neuropathy with dementia and hearing loss (HSN1E) are two rare, overlapping …

The field of mitochondrial epigenetics has received increased attention in recent years and
changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of …

Mitochondrial impairment and increased oxidative stress are common features in
neurodegenerative disorders, leading researchers to speculate that epigenetic changes in …

Skeletal muscle mitochondrial dysfunction is believed to play a role in the progression and
severity of amyotrophic lateral sclerosis (ALS). The regulation of transcriptional co-activators …

Mitochondrial dysfunction is linked with the etiopathogenesis of Alzheimer disease and
Parkinson disease. Mitochondria are intracellular organelles essential for cell viability and …