Highlights•Bacterial genomes contain C 5-methyl-cytosine, N 4-methyl-cytosine, and N 6-
methyl-adenine.•Base methylation controls DNA–protein interactions.•DNA methylation …

Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …

DNA methylation is known as a universal mechanism of epigenetic regulation in all
kingdoms of life. Particularly, given that prokaryotes lack key elements such as histones and …

The amount of bacterial and archaeal genome sequence and methylome data has greatly
increased over the last decade, enabling new insights into the functional roles of DNA …

Epigenetics is a change in gene expression that is heritable without a change in DNA
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …

Methylation of DNA by the DNA adenine methyltransferase (Dam) provides an epigenetic
signal that influences and regulates numerous physiological processes in the bacterial cell …

An increasing number of studies have reported that bacterial DNA methylation has important
functions beyond the roles in restriction-modification systems, including the ability of …

N6 methylation in adenosine moieties causes changes in DNA structure and can modulate
DNA–protein interactions. In both α-Proteobacteria and γ-Proteobacteria, postreplicative …

In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

N6-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most
bacterial DNA adenine methyltransferases are part of restriction–modification systems …