Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T
cells of infected persons treated with highly active antiretroviral therapy (HAART). This …

DNA methylation of retroviral promoters and enhancers localized in the provirus 5′ long
terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that …

Maintenance of HIV latency in vitro has been linked to methylation of HIV DNA. However,
examinations of the degree of methylation of HIV DNA in the latently infected, resting CD4+ …

Background Human immunodeficiency virus type 1 (HIV-1) latency represents the major
barrier to virus eradication in infected individuals because cells harboring latent HIV-1 …

We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2)
is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the …

Histone deacetylase (HDAC) inhibitors such as valproic acid (VPA) induce the expression of
quiescent proviral human immunodeficiency virus type 1 (HIV-1) and may deplete proviral …

With the development of effective combined anti-retroviral therapy (cART), there is significant
reduction in deaths associated with human immunodeficiency virus type 1 (HIV-1) infection …

The essential transactivator function of the HIV Tat protein is regulated by multiple
posttranslational modifications. Although individual modifications are well characterized …

Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones
located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) …

The development of suitable experimental systems for studying HIV latency in primary cells
that permit detailed biochemical analyses and the screening of drugs is a critical step in the …