New modes of action for endocrine-disrupting chemicals

MM Tabb, B Blumberg - Molecular endocrinology, 2006 - academic.oup.com
Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that
mimic or block the transcriptional activation elicited by naturally circulating steroid hormones …

Mechanisms of action of agrochemicals acting as endocrine disrupting chemicals

GR Warner, VE Mourikes, AM Neff, E Brehm… - Molecular and cellular …, 2020 - Elsevier
Agrochemicals represent a significant class of endocrine disrupting chemicals that humans
and animals around the world are exposed to constantly. Agrochemicals can act as …

Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action

EK Shanle, W Xu - Chemical research in toxicology, 2011 - ACS Publications
Many endocrine disrupting chemicals (EDCs) adversely impact estrogen signaling by
interacting with two estrogen receptors (ERs): ERα and ERβ. Though the receptors have …

Assessment and Molecular Actions of Endocrine‐Disrupting Chemicals That Interfere with Estrogen Receptor Pathways

G Kerdivel, D Habauzit, F Pakdel - International Journal of …, 2013 - Wiley Online Library
In all vertebrate species, estrogens play a crucial role in the development, growth, and
function of reproductive and nonreproductive tissues. A large number of natural or synthetic …

Understanding epigenetic effects of endocrine disrupting chemicals: from mechanisms to novel test methods

A Alavian‐Ghavanini, J Rüegg - Basic & clinical pharmacology …, 2018 - Wiley Online Library
Endocrine‐disrupting chemicals (EDC s) are man‐made chemicals that interfere with
hormonal signalling pathways. They are used in, for example, production of common …

Endocrine disruptors: from endocrine to metabolic disruption

C Casals-Casas, B Desvergne - Annual review of physiology, 2011 - annualreviews.org
Synthetic chemicals currently used in a variety of industrial and agricultural applications are
leading to widespread contamination of the environment. Even though the intended uses of …

Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals

JA McLachlan - Endocrine reviews, 2001 - academic.oup.com
The term “endocrine disrupting chemicals” is commonly used to describe environmental
agents that alter the endocrine system. Laboratories working in this emerging field …

Endocrine-disrupting chemicals: an Endocrine Society scientific statement

E Diamanti-Kandarakis, JP Bourguignon… - Endocrine …, 2009 - academic.oup.com
There is growing interest in the possible health threat posed by endocrine-disrupting
chemicals (EDCs), which are substances in our environment, food, and consumer products …

Environmental signaling: a biological context for endocrine disruption.

AO Cheek, PM Vonier, E Oberdörster… - Environmental …, 1998 - ehp.niehs.nih.gov
Endogenous and exogenous chemical signals have evolved as a means for organisms to
respond to physical or biological stimuli in the environment. Sensitivity to these signals can …

Molecular mechanism (s) of endocrine‐disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors

HR Lee, EB Jeung, MH Cho, TH Kim… - Journal of cellular …, 2013 - Wiley Online Library
Endocrine‐disrupting chemicals (EDC s) are natural or synthetic compounds present in the
environment which can interfere with hormone synthesis and normal physiological functions …