Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific
manner. In recent years, such methods have been applied to uncover causal relationships …

Zebrafish became a model of choice for neurobiology because of the transparency of its
brain and because of its amenability to genetic manipulation. In particular, at early stages of …

Optogenetics, the use of light-based protein tools, has begun to revolutionize biological
research. The approach has proven especially useful in the nervous system, where light has …

Optogenetics has revolutionized the toolbox arsenal that neuroscientists now possess to
investigate neuronal circuit function in intact and living animals. With a combination of light …

Zebrafish provide unique opportunities for optogenetic studies of behavior. Here, we review
the most recent work using optogenetic and imaging approaches to study the neuronal …

The conditional expression of transgenes at high levels in sparse and specific populations of
neurons is important for high-resolution optogenetic analyses of neuronal circuits. We …

Methods to label neurons and to monitor their activity with genetically encoded fluorescent
reporters have been a staple of neuroscience research for several years. The recent …

The ability to probe defined neural circuits in awake, freely-moving animals with cell-type
specificity, spatial precision, and high temporal resolution has been a long sought tool for …

The recent development of light-activated optogenetic probes allows for the identification
and manipulation of specific neural populations and their connections in awake animals with …

In a departure from previous top-down or bottom-up strategies used to understand neuronal
circuits, many forward-looking research programs now place the circuit itself at their centre …