Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …

Huntington's disease (HD) is a neurodegenerative disease triggered by expansion of
polyglutamine repeats in the protein huntingtin. Mutant huntingtin (mHtt) aggregates and …

Huntington's disease (HD) is the most common polyglutamine neurodegenerative disorder
in humans, and is caused by a mutation of an unstable expansion of CAG repeats within the …

Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
progressive development of involuntary choreiform movements, cognitive impairment …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder
characterized by progressive motor dysfunction, emotional disturbances, dementia, and …

Huntington's disease (HD) is genetically caused by mutation of the Huntingtin (HTT) gene. At
present, the mechanisms underlying the defect of HTT and the development of HD remain …

Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the
expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant …

Highlights•Transcriptional dysregulationoccurs early in Huntington's disease (HD).•Mutant
huntingtin causes mitochondrial, ER and oxidative stress.•Normal cells compensate for …

Huntington's disease (HD) is a prototypical neurodegenerative disease in which there is
selective neuronal degeneration, which leads to progressive disability, manifesting itself as …

Oxidative stress contributes to neurodegeneration in Huntington's disease (HD). However,
the origins of oxidative stress in HD remain unclear. Studies in HD transgenic models …