We have used a combination of genetics and pharmacology to assess the effects of reduced
DNA methyltransferase activity on ApcM~"-induced intestinal neoplasia in mice. A reduction …

DNA methylation abnormalities occur consistently in human neoplasia including widespread
hypomethylation and more recently recognized local increases in DNA methylation that hold …

DNA methylation appears to play an important role in both physiological and experimentally
modified gene expression, and alterations in DNA methylation have been described in …

Abnormal regional increases in DNA methylation, which have potential for causing gene
inactivation and chromosomal instability, are consistently found in immortalized and …

Background: Molecular changes during progressive stages of colon cancer and other
human tumors commonly involve altered regulation of DNA methylation. These changes …

Epigenetic alterations in the genome of tumor cells have attracted considerable attention
since the discovery of widespread alterations in DNA methylation of colorectal cancers over …

Many tumor cell lines overexpress DNA methyltransferase (MeTase) activity; however it is
still unclear whether this increase in DNA MeTase activity plays a causal role in naturally …

There is considerable interest in the role that DNA methylation (5-methylcytosine [5MeC]
content of DNA) plays in both normal development (Razin and Kafri, 1994) and …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

Changes in the pattern of DNA methylation have been a consistent finding in cancer cells.
The mostly descriptive nature of these studies and the fact that both hypo-and …