Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm
B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …
Pharmacologic management of aneurysms
JH Lindeman, JS Matsumura - Circulation research, 2019 - Am Heart Assoc
Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …
of larger aneurysms. Great potential exists for successful medical therapy that halts or …
[HTML][HTML] The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
Pharmacological treatment of abdominal aortic aneurysm
T Miyake, R Morishita - Cardiovascular research, 2009 - academic.oup.com
Abdominal aortic aneurysm (AAA) is a common degenerative condition with high mortality in
older men. Elective surgical or endovascular repair is performed to prevent rupture of large …
older men. Elective surgical or endovascular repair is performed to prevent rupture of large …
Pathogenesis of abdominal aortic aneurysm: an update and look toward the future
JJ Grange, V Davis, BT Baxter - Cardiovascular surgery, 1997 - Elsevier
To date, aneurysm research has been primarily descriptive, reiterating the complex nature of
the disease process. Enhanced by the convergence of matrix biochemistry, cell biology and …
the disease process. Enhanced by the convergence of matrix biochemistry, cell biology and …
Current status and perspectives on pharmacologic therapy for abdominal aortic aneurysm
K Yoshimura, N Morikage… - Current drug …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …
[HTML][HTML] Matrix metalloproteinase in abdominal aortic aneurysm and aortic dissection
Abdominal Aortic Aneurysm (AAA) affects 4–5% of men over 65, and Aortic Dissection (AD)
is a life-threatening aortic pathology associated with high morbidity and mortality. Initiators of …
is a life-threatening aortic pathology associated with high morbidity and mortality. Initiators of …
Potential role for anti‐angiogenic therapy in abdominal aortic aneurysms
Objective Abdominal aortic aneurysm (AAA) is a condition that mainly affects elderly men. At
present, there is no effective medical therapy that can retard aneurysm growth or prevent …
present, there is no effective medical therapy that can retard aneurysm growth or prevent …
Systematic review and meta-analysis of interventions to slow progression of abdominal aortic aneurysm in mouse models
Objective: There are no current effective abdominal aortic aneurysm (AAA) drug therapies.
An important limitation of most preclinical studies is that they test the effect of drugs on AAA …
An important limitation of most preclinical studies is that they test the effect of drugs on AAA …
[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth
J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …