Polycomb-group proteins assemble into two primary complexes—Polycomb repressive
complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new …

Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …

Polycomb complexes establish chromatin modifications for maintaining gene repression and
are essential for embryonic development in mice. Here we use pluripotent embryonic stem …

The Polycomb system modifies chromatin and plays an essential role in repressing gene
expression to control normal mammalian development. However, the components and …

Polycomb proteins are epigenetic regulators that localize to developmental loci in the early
embryo where they mediate lineage-specific gene repression. In Drosophila, these …

Abstract Polycomb repressive complexes-1 and-2 (PRC1 and 2) silence developmental
genes in a spatiotemporal manner during embryogenesis. How Polycomb group (PcG) …

The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the
ability to differentiate into virtually all adult cell types are not well understood. Polycomb …

Abstract Development of multicellular animals requires epigenetic repression by Polycomb
group proteins. The latter assemble in multi-subunit complexes, of which two kinds …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

Polycomb group proteins maintain the gene-expression pattern of different cells that is set
during early development by regulating chromatin structure. In mammals, two main …