Purpose: We utilized whole-genome mapping of promoters that are activated by DNA
hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel …

We use hepatic cellular carcinoma (HCC), one of the most common human cancers, as a
model to delineate the landscape of promoter hypomethylation in cancer. Using a …

Background & Aims Epigenetic silencing of tumor suppressor genes contributes to the
pathogenesis of hepatocellular carcinoma (HCC). To identify clinically relevant tumor …

Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We
aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular …

To identify new tumor‐suppressor gene candidates relevant for human
hepatocarcinogenesis, we performed genome‐wide methylation profiling and vertical …

Despite progress in the treatment of hepatocellular carcinoma (HCC), 5‐year survival rates
remain low. Thus, a more comprehensive approach to explore the mechanism of HCC is …

Background Aberrant methylation of DNA is a key driver of hepatocellular carcinoma (HCC).
In this study, we sought to integrate four cohorts profile datasets to identify such abnormally …

Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in
hepatocellular carcinoma - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis.
However, its mechanism and implications in hepatocellular carcinogenesis remain to be …

Abstract Background Differences in 5-hydroxymethylcytosine, 5hmC, distributions may
complicate previous observations of abnormal cytosine methylation statuses that are used …