How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Role of vascular smooth muscle cell phenotype switching in arteriogenesis

JV Ashraf, A Al Haj Zen - International journal of molecular sciences, 2021 - mdpi.com
Arteriogenesis is one of the primary physiological means by which the circulatory collateral
system restores blood flow after significant arterial occlusion in peripheral arterial disease …

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

A Frismantiene, M Philippova, P Erne, TJ Resink - Cellular signalling, 2018 - Elsevier
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Vascular smooth muscle cells phenotypic switching in cardiovascular diseases

HY Tang, AQ Chen, H Zhang, XF Gao, XQ Kong… - Cells, 2022 - mdpi.com
Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a
contractile phenotype that maintains the normal vessel structure and function under …

[HTML][HTML] Targeting smooth muscle cell phenotypic switching in vascular disease

R Chakraborty, P Chatterjee, JM Dave, AC Ostriker… - JVS-vascular …, 2021 - Elsevier
Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis

F Zhang, X Guo, Y Xia, L Mao - Cellular and Molecular Life Sciences, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases

MD Worssam, HF Jørgensen - Biochemical Society Transactions, 2021 - portlandpress.com
In contrast with the heart, the adult mammalian vasculature retains significant remodelling
capacity, dysregulation of which is implicated in disease development. In particular, vascular …

An overview of potential molecular mechanisms involved in VSMC phenotypic modulation

MJ Zhang, Y Zhou, L Chen, YQ Wang, X Wang… - Histochemistry and cell …, 2016 - Springer
The fully differentiated medial vascular smooth muscle cells (VSMCs) of mature vessels
keep quiescent and contractile. However, VSMC can exhibit the plasticity in phenotype …

[HTML][HTML] Regulation of vascular smooth muscle cell differentiation

EM Rzucidlo, KA Martin, RJ Powell - Journal of vascular surgery, 2007 - Elsevier
Vascular smooth muscle cell (VSMC) differentiation is an essential component of vascular
development. These cells perform biosynthetic, proliferative, and contractile roles in the …

Fate and state of vascular smooth muscle cells in atherosclerosis

JM Miano, EA Fisher, MW Majesky - Circulation, 2021 - Am Heart Assoc
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …