[HTML][HTML] Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells

M Rao - Developmental biology, 2004 - Elsevier
The past few years have seen remarkable progress in our understanding of embryonic stem
cell (ES cell) biology. The necessity of examining human ES cells in culture, coupled with …

Molecular mechanisms involved in self‐renewal and pluripotency of embryonic stem cells

N Liu, M Lu, X Tian, Z Han - Journal of cellular physiology, 2007 - Wiley Online Library
Embryonic stem cells (ES cells) are derived from inner cell mass (ICM). The self‐renewal
and pluripotency are the main specificities of ES cells, which are likely to reveal a deeper …

The regulation of self-renewal in human embryonic stem cells

S Avery, K Inniss, H Moore - Stem cells and development, 2006 - liebertpub.com
Human embryonic stem (hES) cells have the ability to self-renew while maintaining their
pluripotency. The ability of stem cells to self-renew expansively is essential in both …

Diverse mechanisms regulate stem cell self-renewal

AV Molofsky, R Pardal, SJ Morrison - Current opinion in cell biology, 2004 - Elsevier
To what extent are the pathways that regulate self-renewal conserved between stem cells at
different stages of development and in different tissues? Some pathways play a strikingly …

Mechanisms controlling embryonic stem cell self-renewal and differentiation

Y Sun, H Li, H Yang, MS Rao… - Critical Reviews™ in …, 2006 - dl.begellhouse.com
Embryonic stem (ES) cells are pluripotent cells with indefinite replication potential and ability
to differentiate into all types of cells. An understanding of the regulatory mechanisms …

Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network

G Huang, S Ye, X Zhou, D Liu, QL Ying - Cellular and molecular life …, 2015 - Springer
Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the
capacity to generate any type of cell in the body, and therefore not only hold great promise …

Gene expression heterogeneities in embryonic stem cell populations: origin and function

AM Arias, JM Brickman - Current opinion in cell biology, 2011 - Elsevier
Stem and progenitor cells are populations of cells that retain the capacity to populate
specific lineages and to transit this capacity through cell division. However, attempts to …

Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

KA Becker, PN Ghule, JA Therrien… - Journal of cellular …, 2006 - Wiley Online Library
Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency.
However, there is a critical paucity of fundamental parameters of human ES cell division. In …

Self-renewal vs. differentiation of mouse embryonic stem cells

KS O'Shea - Biology of reproduction, 2004 - academic.oup.com
Embryonic stem (ES) cells are typically derived from the inner cell mass of the
preimplantation blastocyst and can both self-renew and differentiate into all the cells and …

[PDF][PDF] Unraveling epigenetic regulation in embryonic stem cells

M Bibikova, LC Laurent, B Ren, JF Loring, JB Fan - Cell stem cell, 2008 - cell.com
Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to
differentiate into functionally distinct cell types. ES cells proliferate and differentiate without …