Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control …

JC Chambers, M Loh, B Lehne, A Drong… - The lancet Diabetes & …, 2015 - thelancet.com
Summary Background Indian Asians, who make up a quarter of the world's population, are
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …

Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults

I Florath, K Butterbach, J Heiss, M Bewerunge-Hudler… - Diabetologia, 2016 - Springer
Aims/hypothesis Development of type 2 diabetes depends on environmental and genetic
factors. We investigated the epigenome-wide association of prevalent diabetes with DNA …

DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1c levels: a systematic review and replication in a case–control sample of the …

E Walaszczyk, M Luijten, AMW Spijkerman, MJ Bonder… - Diabetologia, 2018 - Springer
Aims/hypothesis Epigenetic mechanisms may play an important role in the aetiology of type
2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA …

Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood

G Toperoff, D Aran, JD Kark… - Human molecular …, 2012 - academic.oup.com
Inter-individual DNA methylation variations were frequently hypothesized to alter individual
susceptibility to Type 2 Diabetes Mellitus (T2DM). Sequence-influenced methylations were …

Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

E Fraszczyk, AMW Spijkerman, Y Zhang, S Brandmaier… - Diabetologia, 2022 - Springer
Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing
prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic …

Epigenome-wide association study in whole blood on type 2 diabetes among sub-Saharan African individuals: findings from the RODAM study

KAC Meeks, P Henneman, A Venema… - International journal …, 2019 - academic.oup.com
Abstract Background Type 2 diabetes (T2D) results from a complex interplay between
genetics and the environment. Several epigenome-wide association studies (EWAS) have …

Association between DNA methylation in whole blood and measures of glucose metabolism: KORA F4 study

J Kriebel, C Herder, W Rathmann, S Wahl, S Kunze… - PloS one, 2016 - journals.plos.org
Epigenetic regulation has been postulated to affect glucose metabolism, insulin sensitivity
and the risk of type 2 diabetes. Therefore, we performed an epigenome-wide association …

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

T Dayeh, T Tuomi, P Almgren, A Perfilyev… - Epigenetics, 2016 - Taylor & Francis
Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental
for prevention of the disease. Consequently, it is essential to search for new biomarkers that …

Blood-based DNA methylation biomarkers for type 2 diabetes: potential for clinical applications

T Willmer, R Johnson, J Louw, C Pheiffer - Frontiers in endocrinology, 2018 - frontiersin.org
Type 2 diabetes (T2D) is a leading cause of death and disability worldwide. It is a chronic
metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental …

[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans

C Davegårdh, S García-Calzón, K Bacos, C Ling - Molecular metabolism, 2018 - Elsevier
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …