The normal aging process is a complex phenomenon associated with physiological
alterations in the function of cells and organs over time. Although an attractive candidate for …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …

The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic
patterns during aging) is the gradual decrease of global DNA methylation. Aging cells …

The genomic hypomethylation hypothesis of aging proposes that an overall decrease in
global DNA methylation occurs with age, and it has been argued that the decrease in global …

The biochemistry of aging is complex, with biologically significant changes occurring in
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …

Aging is characterized by numerous molecular changes, such as accumulation of molecular
damage and altered gene expression, many of which are linked to DNA methylation. Here …

Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA
methylation has been suggested to be a central mechanism in development, some disease …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …

Background Changes to the epigenome with aging, and DNA modifications in particular,
have been proposed as a central regulator of the aging process, a predictor of mortality, and …