Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-
methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by …
methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by …
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic
imprinting, and suppression of transposable elements. 5mC can be converted to 5 …
imprinting, and suppression of transposable elements. 5mC can be converted to 5 …
Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos
Although global erasure of DNA methylation has been observed in zygotes and primordial
germ cells, the responsible enzyme (s) have been elusive. The demonstration that members …
germ cells, the responsible enzyme (s) have been elusive. The demonstration that members …
Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics
The TET family of dioxygenases can oxidize 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in …
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in …
Structural insight into substrate preference for TET-mediated oxidation
DNA methylation is an important epigenetic modification,,. Ten-eleven translocation (TET)
proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine …
proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine …
Charting oxidized methylcytosines at base resolution
DNA cytosine methylation is a key epigenetic mark that is required for normal mammalian
development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA …
development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA …
TET enzymes, TDG and the dynamics of DNA demethylation
DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …
Although enzymes that catalyse DNA methylation have been well characterized, those that …
Direct decarboxylation of ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation
Y Feng, JJ Chen, NB Xie, JH Ding, XJ You, WB Tao… - Chemical …, 2021 - pubs.rsc.org
DNA cytosine methylation (5-methylcytosine, 5mC) is the most important epigenetic mark in
higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA …
higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA …
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
DNA cytosine methylation is crucial for retrotransposon silencing and mammalian
development. In a computational search for enzymes that could modify 5-methylcytosine …
development. In a computational search for enzymes that could modify 5-methylcytosine …
TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …