Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease
JC Chang - Thrombosis journal, 2019 - Springer
In addition to protective “immune response”, sepsis is characterized by destructive
“endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction …
“endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction …
Acute respiratory distress syndrome as an organ phenotype of vascular microthrombotic disease: based on hemostatic theory and endothelial molecular pathogenesis
JC Chang - Clinical and Applied Thrombosis/Hemostasis, 2019 - journals.sagepub.com
Acute respiratory distress syndrome (ARDS) is a life-threatening noncardiogenic circulatory
disorder of the lungs associated with critical illnesses such as sepsis, trauma, and immune …
disorder of the lungs associated with critical illnesses such as sepsis, trauma, and immune …
Biological basis and pathological relevance of microvascular thrombosis
S Pfeiler, S Massberg, B Engelmann - Thrombosis research, 2014 - Elsevier
Microvascular thrombosis indicates a pathological occlusion of microvessels by fibrin-and/or
platelet-rich thrombi. It is observed during systemic infections, cancer, myocardial infarction …
platelet-rich thrombi. It is observed during systemic infections, cancer, myocardial infarction …
Reprint of Crosstalk between inflammation and thrombosis
CT Esmon - Maturitas, 2008 - Elsevier
Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Multiple mechanisms
are at play including up regulation of tissue factor leading to the initiation of clotting …
are at play including up regulation of tissue factor leading to the initiation of clotting …
Disseminated intravascular coagulation: new identity as endotheliopathy-associated vascular microthrombotic disease based on in vivo hemostasis and endothelial …
JC Chang - Thrombosis Journal, 2020 - Springer
Disseminated intravascular coagulation (DIC) can be correctly redefined as disseminated
intravascular microthrombosis based on “two-path unifying theory” of in vivo …
intravascular microthrombosis based on “two-path unifying theory” of in vivo …
Microvascular thrombosis: experimental and clinical implications
MA Bray, SE Sartain, J Gollamudi, RE Rumbaut - Translational Research, 2020 - Elsevier
A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
Endothelial cells: source, barrier, and target of defensive mediators
LT Roumenina, J Rayes, M Frimat… - Immunological …, 2016 - Wiley Online Library
Endothelium is strategically located at the interface between blood and interstitial tissues,
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …
Inflammation, endothelium, and coagulation in sepsis
M Schouten, WJ Wiersinga, M Levi… - Journal of Leucocyte …, 2008 - academic.oup.com
Sepsis is a systemic response to infection, and symptoms are produced by host defense
systems rather than by the invading pathogens. Amongst the most prominent features of …
systems rather than by the invading pathogens. Amongst the most prominent features of …
Sepsis-induced coagulopathy and disseminated intravascular coagulation
Disseminated intravascular coagulation (DIC) has been recognized as a deadly
complication in sepsis, and its early recognition followed by appropriate management of the …
complication in sepsis, and its early recognition followed by appropriate management of the …
From neutrophil extracellular traps release to thrombosis: an overshooting host‐defense mechanism?
JI Borissoff, H Ten Cate - Journal of thrombosis and haemostasis, 2011 - jthjournal.org
Innate immunity and blood coagulation are evolutionary entangled in an intricate network of
molecular and cellular interactions, thus forming an integral part of the host-defense system …
molecular and cellular interactions, thus forming an integral part of the host-defense system …