In addition to protective “immune response”, sepsis is characterized by destructive
“endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction …

Acute respiratory distress syndrome (ARDS) is a life-threatening noncardiogenic circulatory
disorder of the lungs associated with critical illnesses such as sepsis, trauma, and immune …

Microvascular thrombosis indicates a pathological occlusion of microvessels by fibrin-and/or
platelet-rich thrombi. It is observed during systemic infections, cancer, myocardial infarction …

Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Multiple mechanisms
are at play including up regulation of tissue factor leading to the initiation of clotting …

Disseminated intravascular coagulation (DIC) can be correctly redefined as disseminated
intravascular microthrombosis based on “two-path unifying theory” of in vivo …

A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …

Endothelium is strategically located at the interface between blood and interstitial tissues,
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …

Sepsis is a systemic response to infection, and symptoms are produced by host defense
systems rather than by the invading pathogens. Amongst the most prominent features of …

Disseminated intravascular coagulation (DIC) has been recognized as a deadly
complication in sepsis, and its early recognition followed by appropriate management of the …

Innate immunity and blood coagulation are evolutionary entangled in an intricate network of
molecular and cellular interactions, thus forming an integral part of the host-defense system …