Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …

The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

Adrenal cortical carcinoma (ACC) is a rare and aggressive malignancy that poses
challenging issues regarding the diagnostic workup. Indeed, no presurgical technique or …

Adrenal cortical tumors constitute a heterogeneous group of neoplasms with distinct clinical,
morphological, and molecular features. Recent discoveries of specific genotype–phenotype …

Careful morphological evaluation forms the basis of the workup of an adrenal cortical
neoplasm. However, the adoption of immunohistochemical biomarkers has added …

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence worldwide of 0.7–
2.0 cases/million/year. Initial staging is the most important factor in determining prognosis. If …

The diagnosis of low-grade adrenal cortical carcinoma (ACC) confined to the adrenal gland
can be challenging. Although there are diagnostic and prognostic molecular tests for ACC …

The last decade witnessed the emergence of genomics, a set of high-throughput molecular
measurements in biological samples. These pan-genomic and agnostic approaches have …

The adrenal glands are paired endocrine organs that produce steroid hormones and
catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal …

Adrenocortical carcinoma (ACC) is an aggressive and rare neoplasm that originates in the
cortex of the adrenal gland. The disease is associated with heterogeneous but mostly poor …