A review of calibrated blood oxygenation level‐dependent (BOLD) methods for the measurement of task‐induced changes in brain oxygen metabolism

NP Blockley, VEM Griffeth, AB Simon… - NMR in …, 2013 - Wiley Online Library
The dynamics of the blood oxygenation level‐dependent (BOLD) response are dependent
on changes in cerebral blood flow, cerebral blood volume and the cerebral metabolic rate of …

Blood oxygenation level‐dependent (BOLD)‐based techniques for the quantification of brain hemodynamic and metabolic properties–theoretical models and …

DA Yablonskiy, AL Sukstanskii, X He - NMR in Biomedicine, 2013 - Wiley Online Library
The quantitative evaluation of brain hemodynamics and metabolism, particularly the
relationship between brain function and oxygen utilization, is important for the …

A general analysis of calibrated BOLD methodology for measuring CMRO2 responses: comparison of a new approach with existing methods

NP Blockley, VEM Griffeth, RB Buxton - Neuroimage, 2012 - Elsevier
The amplitude of the BOLD response to a stimulus is not only determined by changes in
cerebral blood flow (CBF) and oxygen metabolism (CMRO2), but also by baseline …

A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: modeling the effects of blood volume distribution …

VEM Griffeth, RB Buxton - Neuroimage, 2011 - Elsevier
Calibrated blood oxygenation level dependent (BOLD) imaging, a technique used to
measure changes in cerebral O2 metabolism, depends on an accurate model of how the …

[HTML][HTML] Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism

R Buxton - Frontiers in neuroenergetics, 2010 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …

Understanding the dynamic relationship between cerebral blood flow and the BOLD signal: Implications for quantitative functional MRI

AB Simon, RB Buxton - Neuroimage, 2015 - Elsevier
Calibrated BOLD imaging, in which traditional measurements of the BOLD signal are
combined with measurements of cerebral blood flow (CBF) within a BOLD biophysical …

Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI

BM Ances, O Leontiev, JE Perthen, C Liang… - Neuroimage, 2008 - Elsevier
Functional magnetic resonance imaging (fMRI) based on blood oxygenation level
dependent (BOLD) signal changes is a sensitive tool for mapping brain activation, but …

[HTML][HTML] A streamlined acquisition for mapping baseline brain oxygenation using quantitative BOLD

AJ Stone, NP Blockley - Neuroimage, 2017 - Elsevier
Quantitative BOLD (qBOLD) is a non-invasive MR technique capable of producing
quantitative measurements of the haemodynamic and metabolic properties of the brain …

BOLD‐specific cerebral blood volume and blood flow changes during neuronal activation in humans

JJ Chen, GB Pike - … : An International Journal Devoted to the …, 2009 - Wiley Online Library
To understand and predict the blood‐oxygenation level‐dependent (BOLD) fMRI signal, an
accurate knowledge of the relationship between cerebral blood flow (ΔCBF) and volume …

CBF/CMRO2 coupling measured with calibrated BOLD fMRI: sources of bias

O Leontiev, DJ Dubowitz, RB Buxton - Neuroimage, 2007 - Elsevier
The coupling between cerebral blood flow (CBF) and cerebral metabolic rate of oxygen
(CMRO2) during brain activation can be characterized by an empirical index n, the ratio of …