Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological

DM Bailey, P Bärtsch, M Knauth… - Cellular and Molecular …, 2009 - Springer
Acute mountain sickness (AMS) is a neurological disorder that typically affects mountaineers
who ascend to high altitude. The symptoms have traditionally been ascribed to intracranial …

High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?

REF Turner, H Gatterer, M Falla… - Journal of Applied …, 2021 - journals.physiology.org
High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Frontiers of hypoxia research: acute mountain sickness

RC Roach, PH Hackett - Journal of Experimental Biology, 2001 - journals.biologists.com
Traditionally, scientists and clinicians have explored peripheral physiological responses to
acute hypoxia to explain the pathophysiological processes that lead to acute mountain …

Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness

K Kallenberg, DM Bailey, S Christ… - Journal of Cerebral …, 2007 - journals.sagepub.com
The present study applied T2-and diffusion-weighted magnetic resonance imaging to
examine if mild cerebral edema and subsequent brain swelling are implicated in the …

High altitude cerebral edema and acute mountain sickness: a pathophysiology update

PH Hackett - Hypoxia: into the next millennium, 1999 - Springer
The diagnosis, treatment and prevention of high altitude cerebral edema (HACE) are fairly
well established. The major unresolved issues are 1) the pathophysiology, 2) the individual …

The cerebral etiology of high-altitude cerebral edema and acute mountain sickness

PH Hackett - Wilderness & environmental medicine, 1999 - Elsevier
Acute mountain sickness (AMS) and high-altitude cerebral edema (HACE) are essentially
neurological disorders. The five symptoms included in the Lake Louise AMS symptom score …

Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study

GG Schoonman, PS Sándor… - Journal of Cerebral …, 2008 - journals.sagepub.com
Acute mountain sickness is common among not acclimatized persons ascending to high
altitude; the underlying mechanism is unknown, but may be related to cerebral edema. Nine …

Magnetic resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema

RS Sagoo, CE Hutchinson, A Wright… - Journal of Cerebral …, 2017 - journals.sagepub.com
Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion
potentially fatal high-altitude cerebral edema. The exact pathophysiological mechanisms …

Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache

DM Bailey, R Roukens, M Knauth… - Journal of Cerebral …, 2006 - journals.sagepub.com
The present study combined molecular and neuroimaging techniques to examine if free
radical-mediated damage to barrier function in hypoxia would result in extracellular edema …

High altitude cerebral edema: improving treatment options

R Zelmanovich, K Pierre, P Felisma, D Cole… - Biologics, 2022 - mdpi.com
High altitude illness in its most severe form can lead to high altitude cerebral edema
(HACE). Current strategies have focused on prevention with graduated ascents …