Abstract Purpose: Aberrant methylation of CpG islands can be a good molecular marker for
identifying genes inactivated in cancer. We found the proapoptotic gene HRK to be a target …

AIM: To identify the relationship between DNA hyper-methylation and histone modification at
a hyperme-thylated, silenced tumor suppressor gene promoter in human gastric cancer cell …

OBJECTIVES Recent studies in selected human tumors have demonstrated reduced
expression of HRK with hypermethylation. Because no similar study has been performed …

Cancer development and progression is dictated by a series of alterations in genes such as
oncogenes, tumor suppressor genes, DNA repair genes, and others. DNA methylation is an …

Aberrant promoter DNA-hypermethylation and repressive chromatin constitutes a frequent
mechanism of gene inactivation in cancer. There is great interest in dissecting the …

Promoter CpG island hypermethylation has become recognized as an important mechanism
for inactivating tumor suppressor genes or tumor-related genes in human cancers of various …

CpG island hypermethylation (CIHM) of tumor suppressor genes is one of the major events
in the gastric carcinogenesis. We aimed to investigate the association between CIHM status …

Aberrant methylation of promoter CpG islands is a major inactivation mechanism of tumour‐
related genes that play a crucial role in the progression of silencing in human cancers …

BACKGROUND Transcriptional silencing by CpG‐island hypermethylation now is believed
to be an important mechanism of tumorigenesis. To date, studies on CpG‐island …

Hypermethylation of CpG islands is associated with silencing of various tumor suppressor
genes. Recent studies on colorectal and gastric cancer have identified a CpG island …