Epigenetics is defined as heritable alterations in gene expression that are not caused by
changes in DNA sequence. Such normal alterations are vital for appropriate differentiation …

DNA methylation and posttranslational histone modifications regulate expression of various
genes independently of changes in the DNA sequence. Such epigenetic mechanisms play …

Epigenetic modifications ensure the maintenance of normal cellular functions, and their
dysregulation is frequently found in many disease states, including cancer. Nowadays, the …

DNA sequence has little bearing on the dynamic and heritable changes to the genome that
occur in epigenetics. Both genetic and epigenetic alterations influence the development of …

Epigenetics mainly refers to covalent modifications to DNA or histones without affecting
genomes, which ultimately lead to phenotypic changes in cells or organisms. Given the …

Epigenetic regulation refers to the alteration of gene expression independent of changes in
DNA sequence. It involves chemical modifications such as DNA methylation, histone …

Epigenetic approach in treating different diseases has gained importance as the inhibition of
the enzymes involved in epigenetic modifications can reverse the disease condition. The …

Despite considerable scientific progress, the burden of cancer in our society remains a
major public health problem. Tumorigenesis is recognized as a complex and multistep …

Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

The identification of all epigenetic modifications implicated in gene expression is the next
step for a better understanding of human biology in both normal and pathological states …