RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2
Y Li, L Xia, K Tan, X Ye, Z Zuo, M Li, R Xiao, Z Wang… - Nature …, 2020 - nature.com
A dynamic epigenome is critical for appropriate gene expression in development and
health,,,–. Central to this is the intricate process of transcription,,,,–, which integrates cellular …
health,,,–. Central to this is the intricate process of transcription,,,,–, which integrates cellular …
Emerging links between m6A and misregulated mRNA methylation in cancer
SR Jaffrey, MG Kharas - Genome medicine, 2017 - Springer
Editorial summary N 6-methyladenosine (m 6 A) in mRNA has emerged as a crucial
epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent …
epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent …
[HTML][HTML] The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling
Y Zhao, Y Chen, M Jin, J Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Epigenetic regulation involves a range of sophisticated processes which contribute to
heritable alterations in gene expression without altering DNA sequence. Regulatory events …
heritable alterations in gene expression without altering DNA sequence. Regulatory events …
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis
F Yang, H Jin, B Que, Y Chao, H Zhang, X Ying, Z Zhou… - Oncogene, 2019 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant internal modification in
mammalian mRNAs. Despite its functional importance in various physiological events, the …
mammalian mRNAs. Despite its functional importance in various physiological events, the …
Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma
R Li, H Zhao, X Huang, J Zhang, R Bai, L Zhuang… - Nature Genetics, 2023 - nature.com
The biological functions of noncoding RNA N 6-methyladenosine (m6A) modification remain
poorly understood. In the present study, we depict the landscape of super-enhancer RNA …
poorly understood. In the present study, we depict the landscape of super-enhancer RNA …
Exon junction complex shapes the m6A epitranscriptome
Abstract N6-methyladenosine (m6A), the most abundant modification of mRNA, is essential
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
X Wei, Y Huo, J Pi, Y Gao, S Rao, M He, Q Wei… - Nature cell …, 2022 - nature.com
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets
Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Abstract N 6-methyladenosine (m6A) methylation can be deposited on chromatin-associated
RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state …
RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state …