Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

The mechanisms of action of polycystin-1 (PC1) have been difficult to dissect because of its
interaction with multiple factors, the heterogeneity of the genetic mutations, and the …

Abstract Polycystin-1 (PC1) mutations result in proliferative renal cyst growth and
progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The …

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of
multiple fluid-filled cysts that expand over time and destroy the renal architecture. Loss or …

Mutations of either PKD1 or PKD2 cause autosomal dominant polycystic kidney disease, a
syndrome characterized by extensive formation of renal cysts and progressive renal failure …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, which encode polycystin-1 and polycystin-2, respectively. Rodent models are …

Abstract Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is
characterized by the formation of multiple fluid-filled cysts that destroy the kidney …

Autosomal recessive polycystic kidney disease is caused by mutations in PKHD1, which
encodes the membrane-associated receptor-like protein fibrocystin/polyductin (FPC). FPC …

Autosomal dominant (ADPKD) and autosomal recessive (ARPKD) polycystic kidney disease
are caused by mutations in Pkd1/Pkd2 and Pkhd1, which encode polycystins (PCs) and …