[HTML][HTML] METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity
Epitranscriptomic RNA modifications are crucial for the maintenance of glioma stem cells
(GSCs), the most malignant cells in glioblastoma (GBM). 3-methylcytosine (m3C) is a new …
(GSCs), the most malignant cells in glioblastoma (GBM). 3-methylcytosine (m3C) is a new …
Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
Despite advances in biology and therapeutic modalities, existence of highly tumorigenic
glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine …
glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine …
[HTML][HTML] METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation
Y Huang, J Ma, C Yang, P Wei, M Yang, H Han… - Biomarker …, 2022 - Springer
Background Neuroblastoma (NBL) is the most common extra-cranial solid tumour in
childhood, with prognosis ranging from spontaneous remission to high risk for rapid and …
childhood, with prognosis ranging from spontaneous remission to high risk for rapid and …
[HTML][HTML] N6-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the …
A Visvanathan, V Patil, S Abdulla, JD Hoheisel… - Genes, 2019 - mdpi.com
Despite recent advances in N 6-methyladenosine (m6A) biology, the regulation of crucial
RNA processing steps by the RNA methyltransferase-like 3 (METTL3) in glioma stem-like …
RNA processing steps by the RNA methyltransferase-like 3 (METTL3) in glioma stem-like …
[HTML][HTML] m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells
RNA modifications play critical roles in important biological processes. However, the
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …
N6-Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human Glioblastoma
F Li, Y Yi, Y Miao, W Long, T Long, S Chen, W Cheng… - Cancer research, 2019 - AACR
Abstract The N6-methyladenosine (m6A) modification influences various mRNA metabolic
events and tumorigenesis, however, its functions in nonsense-mediated mRNA decay …
events and tumorigenesis, however, its functions in nonsense-mediated mRNA decay …
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here,
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
[HTML][HTML] METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m7G-modified miR-760-dependent manner
H Xie, M Wang, H Yu, H Wang, L Ding, R Wang… - Cell Death …, 2022 - nature.com
methylguanosine (m7G) modification is recently found to conservatively exist in RNA internal
position besides mRNA caps and mediates the various RNA metabolisms. As the core …
position besides mRNA caps and mediates the various RNA metabolisms. As the core …
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth
Recently, covalent modifications of RNA, such as methylation, have emerged as key
regulators of all aspects of RNA biology and have been implicated in numerous diseases …
regulators of all aspects of RNA biology and have been implicated in numerous diseases …
[HTML][HTML] METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism
J Wang, H Yin, G Li, D Wu, Y Xu, Y Chen, X Wang… - Cell Death …, 2024 - nature.com
Neuroblastoma (NB) is a common childhood tumor with a high incidence worldwide. The
regulatory role of RNA N6-methyladenosine (m6A) in gene expression has attracted …
regulatory role of RNA N6-methyladenosine (m6A) in gene expression has attracted …