DNA methylation is a significant regulator of gene expression, and its role in carcinogenesis
recently has been a subject of remarkable interest. The aim of this review is to analyze the …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

Cancer has been considered a genetic disease with a wide array of well-characterized gene
mutations and chromosomal abnormalities. Of late, aberrant epigenetic modifications have …

DNA methylation is one of several epigenetic changes observed in cells. Aberrant
methylation of tumor suppressor genes, proto-oncogenes, and vital cell cycle genes has led …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

DNA methylation plays an important role in the establishment and maintenance of the
program of gene expression. Tumor cells are characterized by a paradoxical alteration of …

Epigenetic alterations such as DNA methylation have been implicated in the development
and progression of various cancers. DNA methylation consists of the reversible addition of a …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

DNA methylation is one among the major grounds of cancer progression which is
characterized by the addition of a methyl group to the promoter region of the gene thereby …

Epigenetics describes the study of stable, reversible alterations to the genome that affect
gene expression and genome function, the most studied mechanisms are DNA methylation …