Akt1 is critical for many in vivo functions; however, the cell-specific substrates responsible
remain to be defined. Here, we examine the importance of endothelial nitric oxide synthase …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

Objective—The importance of PI3K/Akt signaling in the vasculature has been demonstrated
in several models, as global loss of Akt1 results in impaired postnatal ischemia-and VEGF …

Endothelial nitric oxide synthase (eNOS) is an important modulator of angiogenesis and
vascular tone [1]. It is stimulated by treatment of endothelial cells in a phosphatidylinositol 3 …

The serine/threonine kinase Akt, also named protein kinase B, plays a central role in
promoting the survival of a wide range of cell types. 1 In this issue of Circulation Research …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for
maintaining systemic blood pressure, vascular remodelling and angiogenesis,,,. eNOS is …

Akt, or protein kinase B, is a multifunctional serine-threonine protein kinase implicated in a
diverse range of cellular functions including cell metabolism, survival, migration, and gene …

Background—In hypertension, reduced nitric oxide production and blunted endothelial
vasorelaxation are observed. It was recently reported that AKT phosphorylates and activates …

The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1,
Akt2 and Akt3. Akt activation has been implicated in both normal and disease processes …