Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
[HTML][HTML] Augmenting antitumor immune responses with epigenetic modifying agents
E Héninger, TEG Krueger, JM Lang - Frontiers in immunology, 2015 - frontiersin.org
Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …
Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment
X Pan, L Zheng - Cellular & molecular immunology, 2020 - nature.com
Epigenetic regulation of gene expression in cancer cells has been extensively studied in
recent decades, resulting in the FDA approval of multiple epigenetic agents for treating …
recent decades, resulting in the FDA approval of multiple epigenetic agents for treating …
Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy
I Lodewijk, SP Nunes, R Henrique, C Jerónimo… - Clinical …, 2021 - Springer
Background Epigenetic alterations are known contributors to cancer development and
aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are …
aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are …
[HTML][HTML] Role of epigenetic regulation in plasticity of tumor immune microenvironment
Y Yang, Y Wang - Frontiers in Immunology, 2021 - frontiersin.org
The tumor immune microenvironment (TIME), an immunosuppressive niche, plays a pivotal
role in contributing to the development, progression, and immune escape of various types of …
role in contributing to the development, progression, and immune escape of various types of …
Molecular pathways: at the crossroads of cancer epigenetics and immunotherapy
M Maio, A Covre, E Fratta, AM Di Giacomo… - Clinical Cancer …, 2015 - AACR
Epigenetic regulation allows heritably modulating gene expression profiles without
modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns …
modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns …
Targeting the epigenetic regulation of antitumour immunity
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …
cancer onset and progression. Although defective gene regulation often affects oncogenic …
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal Transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
[HTML][HTML] Epigenetics and immunotherapy: the current state of play
J Dunn, S Rao - Molecular immunology, 2017 - Elsevier
Cancer cells employ a number of mechanisms to escape immunosurveillance and facilitate
tumour progression. The recent explosion of interest in immunotherapy, especially immune …
tumour progression. The recent explosion of interest in immunotherapy, especially immune …
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