Background In the mouse zygote, DNA methylation patterns are heavily modified, and differ
between the maternal and paternal pronucleus. Demethylation of the paternal genome has …

Covalent modification of cytosine nucleotides within the genome encode essential
epigenetic information, with methylation (5meC) and hydroxymethylation (5hmC) having …

Abstract The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic
oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is …

After fertilization, the mammalian embryo undergoes epigenetic reprogramming with
genome‐wide DNA demethylation and subsequent remethylation. Oxidation of 5 …

Following fertilization in mammals, paternal genomic 5-methyl-2′-deoxycytidine (5 mC)
content is thought to decrease via oxidation to 5-hydroxymethyl-2′-deoxycytidine (5 hmC) …

Cytosine methylation is an epigenetically propagated DNA modification that can modify how
the DNA molecule is recognized and expressed. DNA methylation undergoes extensive …

DNA methylation has been studied comprehensively and linked to both normal
neurodevelopment and neurological diseases. The recent identification of several new DNA …

Methylation of cytosine is a DNA modification associated with gene repression. Recently, a
novel cytosine modification, 5-hydroxymethylcytosine (5-hmC) has been discovered. Here …

The epigenomes of early mammalian embryos are extensively reprogrammed to acquire a
totipotent developmental potential. A major initial event in this reprogramming is the active …

5-Hydroxymethyl-cytosine (5-hmC) is a form of modified cytosine, which has recently
attracted a considerable attention due to its potential role in transcriptional regulation …