Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology

SJ Forrester, GW Booz, CD Sigmund… - Physiological …, 2018 - journals.physiology.org
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

AT1 receptor signaling pathways in the cardiovascular system

T Kawai, SJ Forrester, S O'Brien, A Baggett… - Pharmacological …, 2017 - Elsevier
The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …

New insights on signaling cascades induced by cross-talk between angiotensin II and aldosterone

CA Lemarié, P Paradis, EL Schiffrin - Journal of molecular medicine, 2008 - Springer
Abstract Angiotensin II (Ang II) is considered the main final mediator of the renin–
angiotensin–aldosterone system (RAAS). The actions of Ang II have been implicated in …

Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology

S Higuchi, H Ohtsu, H Suzuki, H Shirai… - Clinical …, 2007 - portlandpress.com
The intracellular signal transduction of AngII (angiotensin II) has been implicated in
cardiovascular diseases, such as hypertension, atherosclerosis and restenosis after injury …

Angiotensin II signaling in vascular smooth muscle: new concepts

KK Griendling, M Ushio-Fukai, B Lassègue… - …, 1997 - Am Heart Assoc
Angiotensin II is a multifunctional hormone that affects both contraction and growth of
vascular smooth muscle cells through a complex series of intracellular signaling events …

Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases

S Kim, H Iwao - Pharmacological reviews, 2000 - ASPET
A growing body of evidence supports the notion that angiotensin II (Ang II), the central
product of the renin-angiotensin system, may play a central role not only in the etiology of …

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

PK Mehta, KK Griendling - American Journal of Physiology …, 2007 - journals.physiology.org
The renin-angiotensin system is a central component of the physiological and pathological
responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not …

Angiotensin II signaling pathways mediated by tyrosine kinases

G Yin, C Yan, BC Berk - The international journal of biochemistry & cell …, 2003 - Elsevier
Angiotensin II (AngII) plays a critical role in control of cardiovascular and renal homeostasis.
In addition to its physiological action as a vasoconstrictor, growing evidence supports the …

Recent advances in angiotensin II signaling

RM Touyz, C Berry - Brazilian Journal of Medical and Biological …, 2002 - SciELO Brasil
Angiotensin II (Ang II)* is a multifunctional hormone that influences the function of
cardiovascular cells through a complex series of intracellular signaling events initiated by …

Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells

RM Touyz, EL Schiffrin - Pharmacological reviews, 2000 - ASPET
Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …