Tissue-and developmental stage-specific expression of the human β-like globin genes is
regulated by a combination of ubiquitous and erythroid-restricted trans factors that bind to cis …

The developmental progression of an organism from fertilized egg to intact adult depends
critically on the temporally and spatially precise regulation of specific sets of genes. While …

Previous studies have defined transcriptional control elements, in addition to the promoters,
that both lie near individual human β-globin locus genes and have been implicated in their …

In order to gain further insights of the regulatory mechanisms of human beta-like globin gene
switch during erythroid development, we have studied protein-DNA interaction in vivo at the …

The globin chain synthetic pattern and the extent of DNA methylation within embryonic, fetal,
and adult beta-like globin gene domains were evaluated in greater than or equal to 90 …

The human β-globin locus is a complex genetic system widely used for analysis of
eukaryotic gene expression. The locus consists of five functional β-like globin genes, ε, Gγ …

The developmental control of expression of the human epsilon-globin gene appears to be
mediated, at least in part, by a transcriptional silencer in the DNA 5 'to the cap site of this …

Suggestions that the field of hemoglobin regulation and erythroid cell molecular biology was
undergoing a tortuous and slow death, awash in the scientific community several years ago …

The temporal sequence of expression of human globin genes during development suggests
precise regulation of these genes. Recent studies have characterized a number of DNA …

BCL11A, the major regulator of fetal hemoglobin (HbF, α2γ2) level, represses γ-globin
expression through direct promoter binding in adult erythroid cells in a switch to adult …