Improved persistence to medication, decreased cardiovascular events and reduced all-cause mortality in hypertensive patients with use of single-pill combinations …

RE Schmieder, S Wassmann, HG Predel, B Weisser… - …, 2023 - Am Heart Assoc
Background: Single-pill combination improves adherence and persistence to medication in
hypertension. It remains unclear whether this also reduces cardiovascular outcomes and all …

Improving treatment adherence to antihypertensive therapy: the role of single-pill combinations

S Bangalore, L Ley - Expert Opinion on Pharmacotherapy, 2012 - Taylor & Francis
Introduction: The majority of patients with hypertension require combination therapy to
achieve their blood pressure (BP) goal. Studies have consistently shown that polypharmacy …

The use of single-pill combinations as first-line treatment for hypertension: translating guidelines into clinical practice

E Campana, V Cunha, S Glaveckaite… - Journal of …, 2020 - journals.lww.com
Abstract The 2008 European Society of Cardiology/European Society of Hypertension
guidelines recommend the first-line prescription of two antihypertensive drugs in single-pill …

A medication adherence and persistence comparison of hypertensive patients treated with single-, double-and triple-pill combination therapy

L Xie, F Frech-Tamas, E Marrett… - Current Medical Research …, 2014 - Taylor & Francis
Objective: Fixed-dose combination therapy reduces pill burden and may, therefore, improve
medication adherence and health outcomes. This study compared adherence to and …

[HTML][HTML] Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: a population-based retrospective cohort study

AA Verma, W Khuu, M Tadrous, T Gomes… - PLoS …, 2018 - journals.plos.org
Background The majority of people with hypertension require more than one medication to
achieve blood pressure control. Many patients are prescribed multipill antihypertensive …

Single‐pill vs free‐equivalent combination therapies for hypertension: a meta‐analysis of health care costs and adherence

B Sherrill, M Halpern, S Khan, J Zhang… - The Journal of …, 2011 - Wiley Online Library
J Clin Hypertens (Greenwich). 2011; 13: 898–909.© 2011 Wiley Periodicals, Inc. This meta‐
analysis compares health care resource use costs, adherence, and persistence between …

Issues in blood pressure control and the potential role of single‐pill combination therapies

M Burnier, RE Brown, SH Ong… - … journal of clinical …, 2009 - Wiley Online Library
Hypertension (HTN) is a major risk factor for cardiovascular mortality, yet only a small
proportion of hypertensive individuals receive appropriate therapy and achieve target blood …

[HTML][HTML] Impact of single-pill combination therapy on adherence, blood pressure control, and clinical outcomes: a rapid evidence assessment of recent literature

K Tsioufis, R Kreutz, G Sykara, J van Vugt… - Journal of …, 2020 - journals.lww.com
Objective: The 2018 European Society of Cardiology/European Society of Hypertension
Guidelines for the management of arterial hypertension raised the need for evidence to …

[HTML][HTML] Adherence and related cardiovascular outcomes to single pill vs. separate pill administration of antihypertensive triple-combination therapy

F Rea, G Morabito, L Savaré, A Pathak… - Journal of …, 2023 - journals.lww.com
Objective: To compare adherence to antihypertensive treatment between patients
prescribed a three-drug single-pill combination (SPC) of perindopril/amlodipine/indapamide …

Evaluation of compliance and health care utilization in patients treated with single pill vs. free combination antihypertensives

W Yang, J Chang, KH Kahler, T Fellers… - … medical research and …, 2010 - Taylor & Francis
Objectives: To compare compliance/persistence, health care resource utilization, and costs
associated with single-pill combination (SPC) vs. free-combination (FC) therapies among …