Targeting of proteins in the histone modification machinery has emerged as a promising
new direction to fight disease. The search for compounds that inhibit proteins that readout …

Objective: Short histone 3 peptides are often used for experiments with proteins that
recognize trimethylated lysine on histone 3 (H3K4me3). In this chapter it is investigated what …

Histone post-translational modifications (PTMs) are crucial for many cellular processes
including mitosis, transcription, and DNA repair. The cellular readout of histone PTMs is …

Despite tremendous success in understanding the chemical nature and the importance of
cation− π interactions in a range of biological processes, particularly in epigenetic …

Development of inhibitors for histone methyllysine reader proteins is an active area of
research due to the importance of reader protein–methyllysine interactions in transcriptional …

We report 17 small-molecule ligands that compete with N6-methyladenosine (m6A) for
binding to the m6A-reader domain of YTHDF2 (YT521-B homology domain family 2). We …

Lysine methylation facilitates protein-protein interactions through the activity of methyllysine
(Kme)“reader” proteins. Functions of Kme readers have historically been studied in the …

Methyl-lysine reader (Kme) proteins recognize post-translational modifications, specifically
methyl marks, on histone tails and recruit other chromatin interacting proteins that participate …

Methyl-lysine reader (Kme) proteins recognize post-translational modifications, specifically
methyl marks, on histone tails and recruit other chromatin interacting proteins that participate …

Responsible for interpreting histone post-translational modifications, epigenetic reader
proteins have emerged as novel therapeutic targets for a wide range of diseases. Chemical …