Flow back along a needle track (backflow) can be a problem during direct infusion, eg
convection-enhanced delivery (CED), of drugs into soft tissues such as brain. In this study …

Fluid flow back along the outer surface of a needle (backflow) can be a significant problem
during the direct infusion of drugs into brain tissues for procedures such as convection …

Background Convection enhanced delivery (CED) infuses drugs directly into brain tissue.
Needle insertion is required and results in tissue damage which can promote flowback …

Convection-enhanced delivery (CED) is a rational technique for the direct intracranial
administration of a range of therapeutic agents. CED critically depends on the use of a …

Delivering therapeutic agents into the brain via convection-enhanced delivery (CED), a
mechanically controlled infusion method, provides an efficient approach to bypass the blood …

Object. Although recent studies have shown that convection can be used to distribute
macromolecules within the central nervous system (CNS) in a homogeneous, targeted …

Object In convection-enhanced delivery (CED), drugs are infused locally into tissue through
a cannula inserted into the brain parenchyma to enhance drug penetration over diffusion …

Background Convection-enhanced delivery (CED) is currently the only effective clinical
technique to deliver biological therapeutic agents that would otherwise not cross the blood …

Convection enhanced drug delivery (CED) is a promising therapeutic method for treating
diseases of the brain by enhancing the penetration of drugs. Most controlled release …

Convection enhanced delivery (CED) achieves targeted delivery of drugs with a pressure-
driven infusion through a cannula placed stereotactically in the brain. This technique …