Leigh syndrome is a devastating neurodegenerative disease, typically manifesting in infancy
or early childhood. However, also late-onset cases have been reported. Since its first …

Leigh syndrome is a progressive neurodegenerative disorder, affecting 1 in 40,000 live
births. Most patients present with symptoms between the ages of three and twelve months …

Leigh syndrome, caused by dysfunction in mitochondrial energy metabolism, is an inherited,
heterogeneous, and progressive neurodegenerative disorder of infancy and childhood …

Patients with Leigh syndrome classically present in early childhood with developmental
regression, ataxia, and hypotonia with subsequent respiratory and brainstem dysfunction …

Leigh syndrome by definition is (1) a neurodegenerative disease with variable symptoms,(2)
caused by mitochondrial dysfunction from a hereditary genetic defect and (3) accompanied …

Leigh syndrome is the most common pediatric presentation of mitochondrial disease. This
neurodegenerative disorder is genetically heterogeneous, and to date pathogenic mutations …

Leigh syndrome (also termed subacute, necrotizing encephalopathy) is a devastating
neurodegenerative disorder, characterized by almost identical brain changes, eg, focal …

Background Leigh syndrome is a progressive neurodegenerative disorder, associated with
primary or secondary dysfunction of the mitochondrial oxidative phosphorylation. Despite …

The neurodiagnostic criteria of Leigh syndrome have not yet been clearly redefined based
on the expanding of molecular etiologies. We aimed to analyze 20 years of clinical, genetic …

Leigh Syndrome (OMIM 256000) is a heterogeneous neurologic disorder due to damage in
mitochondrial energy production that usually starts in early childhood. The first description …