Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Retinoids play an important role in development, differentiation, and homeostasis. The
discovery of retinoid receptors belonging to the superfamily of nuclear ligand‐activated …

Retinoic acid (RA) agents possess anti-tumor activity through their ability to induce cellular
differentiation. However, retinoids have not yet been translated into effective systemic …

The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and
RXRs) which are ligand-activated transcription factors. In response to retinoid binding …

Retinoids (retinol [vitamin A] and its biologically active metabolites) are essential signaling
molecules that control various developmental pathways and influence the proliferation and …

Retinoids comprise a group of compounds each composed of three basic parts: a
trimethylated cyclohexene ring that is a bulky hydrophobic group, a conjugated tetraene side …

Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …

The retinoids are a class of compounds that are structurally related to vitamin A. Retinoic
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …

The physiological effects of retinoic acids (RAs) are mediated by members of two families of
nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) …

The three subtypes (α, β, and γ) of the retinoic acid receptor (RAR) are ligand-dependent
transcription factors that mediate retinoic acid signaling by forming heterodimers with the …