Opioids and sensory nerves
C Stein, C Zöllner - Sensory Nerves, 2009 - Springer
This chapter reviews the expression and regulation of opioid receptors in sensory neurons
and the interactions of these receptors with endogenous and exogenous opioid ligands …
and the interactions of these receptors with endogenous and exogenous opioid ligands …
Peripheral mechanisms of opioid analgesia
C Stein, LJ Lang - Current opinion in pharmacology, 2009 - Elsevier
Potent and clinically significant analgesic effects can be brought about by opioids acting
outside the central nervous system. Injury and inflammation of peripheral tissues leads to …
outside the central nervous system. Injury and inflammation of peripheral tissues leads to …
Leukocyte-derived opioid peptides and inhibition of pain
H Machelska, C Stein - Journal of Neuroimmune Pharmacology, 2006 - Springer
In peripheral inflamed tissue interactions between leukocyte-derived opioid peptides and
opioid receptors on sensory neurons lead to potent, clinically relevant inhibition of pain …
opioid receptors on sensory neurons lead to potent, clinically relevant inhibition of pain …
Targeting of opioid-producing leukocytes for pain control
H Machelska - Neuropeptides, 2007 - Elsevier
It is accepted that inflammatory mediators released from leukocytes contribute to the
generation of pain. However, it is less well known that immune cells also produce mediators …
generation of pain. However, it is less well known that immune cells also produce mediators …
Leukocytes in the regulation of pain and analgesia
HL Rittner, H Machelska, C Stein - Journal of leukocyte biology, 2005 - academic.oup.com
When tissue is destroyed or invaded by leukocytes in inflammation, numerous mediators are
delivered by the circulation and/or liberated from resident and immigrated cells at the site …
delivered by the circulation and/or liberated from resident and immigrated cells at the site …
Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications
Peripheral mechanisms of endogenous pain control are significant. In peripheral inflamed
tissue, an interaction between immune-cell-derived opioids and opioid receptors localized …
tissue, an interaction between immune-cell-derived opioids and opioid receptors localized …
Immune mechanisms in pain control
H Machelska, C Stein - Anesthesia & Analgesia, 2002 - journals.lww.com
Classically, pain sensation or suppression has been attributed exclusively to neuronal
circuits. This review challenges this notion and presents an expanded concept about the …
circuits. This review challenges this notion and presents an expanded concept about the …
Cellular mechanisms of excitatory and inhibitory actions of opioids
LYM Huang - The pharmacology of opioid peptides, 1995 - books.google.com
Opioids are major modulators in the nervous system. They modulate synaptic transmission
in nociceptive (pain-sensing) pathways and inhibit the responses of dorsal horn neurons to …
in nociceptive (pain-sensing) pathways and inhibit the responses of dorsal horn neurons to …
Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain–basic and therapeutic aspects
M Busch-Dienstfertig, C Stein - Brain, behavior, and immunity, 2010 - Elsevier
This review summarizes recent findings on neuro-immune mechanisms underlying opioid-
mediated inhibition of pain. The focus is on events occurring in peripheral injured tissues …
mediated inhibition of pain. The focus is on events occurring in peripheral injured tissues …
[HTML][HTML] Opioid receptors on peripheral sensory neurons
C Stein - Madame Curie Bioscience Database [Internet], 2013 - ncbi.nlm.nih.gov
The interaction of immune cell-derived opioid peptides with opioid receptors on peripheral
terminals of primary afferent (sensory) neurons is one of the most extensively investigated …
terminals of primary afferent (sensory) neurons is one of the most extensively investigated …