Cell cycle regulation is orchestrated by a complex network of interactions between proteins,
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …

Normal cell cycle progression relies on the cell's ability to translate extracellular signals such
as mitogenic stimuli and intact extracellular matrices in order to efficiently replicate DNA and …

Cyclins and CDKs play critical roles in DNA synthesis and cell division. Alterations in their
function may lead to the disruption of normal cell growth and apoptosis, and subsequently …

Cancer is frequently considered to be a disease of the cell cycle. As such, it is not surprising
that the deregulation of the cell cycle is one of the most frequent alterations during tumor …

The cell cycle is a highly conserved and ordered set of events, culminating in cell growth
and division. It is tightly controlled by many regulatory mechanisms that either permit or …

Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …

The cell cycle represents a series of tightly integrated events that allow the cell to grow and
proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases …

Uncontrolled proliferation is a hallmark of cancer cells. Molecular analysis of human tumors
and animal models have provided a clear basis for the understanding of the cellular …

Chemotherapy of cancer is limited by its toxicity to normal cells. On the basis of discoveries
in signal transduction and cell cycle regulation, novel mechanism-based therapeutics are …

Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell
cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are …