Background—Excessive proliferation and impaired apoptosis of pulmonary artery (PA)
smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn …

Epigenetics refers to changes in phenotype and gene expression that occur without
alterations in DNA sequence. Epigenetic modifications of the genome can be acquired de …

Studies have demonstrated that increased oxidative stress contributes to the pathogenesis
and the development of pulmonary artery hypertension (PAH). Extracellular superoxide …

Pulmonary arterial hypertension (PAH) is an idiopathic cardiopulmonary disease
characterized by obstruction of small pulmonary arteries. Vascular obstruction is the …

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by
enhanced proliferation and suppressed apoptosis of pulmonary artery smooth muscle cells …

Background—The cause of pulmonary arterial hypertension (PAH) was investigated in
humans and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain …

Significance: The molecular events that promote the development of pulmonary
hypertension (PH) are complex and incompletely understood. The complex interplay …

Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known
cure. Heart failure is a major comorbidity and a common cause of the premature death of …

Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and
function. It is becoming increasingly clear that endothelial cell dysfunction significantly …

Pulmonary hypertension (PH) is characterized by increased pulmonary vascular
remodeling, resistance, and pressures. Reactive oxygen species (ROS) contribute to PH …