Publisher Summary Deoxyribonucleic acid (DNA) methylation, a covalent modification of the
genome, is emerging as an important player in the regulation of gene expression. This …

Introduction 3. DNA methylation marks inactive regions of the genome 3.1. DNA methylation
patterns and chromatin. 3.2. DNA methylation inhibits gene expression by direct and indirect …

The DNA cytosine methyltransferase 1 (DNMT1) is a ubiquitous nuclear enzyme that
catalyzes the well-established reaction of placing methyl groups on the unmethylated …

DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …

In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …

DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is
responsible for maintaining the DNA methylation pattern during cell division. A long list of …

DNA methylation plays a central role in the epigenetic regulation of gene expression in
vertebrates. Genetic and biochemical data indicated that DNA methyltransferase 1 (Dnmt1) …

DNA methylation is a covalent modification of DNA that plays an important role in setting
gene expression programs during development. Recent evidence suggests that changes in …

DNA methylation, the post-replicative transfer of a methyl group to the C5 position of
cytosine bases, was the first epigenetic modification identified and has been intensively …

Global hypomethylation of genes and repetitive sequences, as well as hypermethylation of
certain genes known to be involved in tumor suppression, are observed concurrently in …