[HTML][HTML] Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease

DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …

[HTML][HTML] Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

RJ Reiter, R Sharma, F Simko… - Cellular and Molecular …, 2022 - Springer
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …

COVID-19: Melatonin as a potential adjuvant treatment

R Zhang, X Wang, L Ni, X Di, B Ma, S Niu, C Liu… - Life sciences, 2020 - Elsevier
This article summarizes the likely benefits of melatonin in the attenuation of COVID-19
based on its putative pathogenesis. The recent outbreak of COVID-19 has become a …

[HTML][HTML] Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on …

DX Tan, R Hardeland - Melatonin Research, 2020 - melatonin-research.net
The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19,
and avian flu is often caused by the uncontrolled innate immune response and destructive …

[HTML][HTML] Possible application of melatonin in long COVID

DP Cardinali, GM Brown, SR Pandi-Perumal - Biomolecules, 2022 - mdpi.com
Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger
for months beyond the acute stage of SARS-CoV-2 infection,“long COVID”. Among the long …

Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

DX Tan, RJ Reiter - Life Sciences, 2022 - Elsevier
The fear of SARS-CoV-2 infection is due to its high mortality related to seasonal flu. To date,
few medicines have been developed to significantly reduce the mortality of the severe …

[HTML][HTML] Can melatonin be a potential “silver bullet” in treating COVID-19 patients?

DP Cardinali, GM Brown, SR Pandi-Perumal - Diseases, 2020 - mdpi.com
The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract
the consequences of COVID-19 infections has been advocated. Because of its wide-ranging …

[HTML][HTML] Targeting host defense system and rescuing compromised mitochondria to increase tolerance against pathogens by melatonin may impact outcome of deadly …

DX Tan, R Hardeland - Molecules, 2020 - mdpi.com
Fighting infectious diseases, particularly viral infections, is a demanding task for human
health. Targeting the pathogens or targeting the host are different strategies, but with an …

[HTML][HTML] Therapeutic algorithm for use of melatonin in patients with COVID-19

RJ Reiter, P Abreu-Gonzalez, PE Marik… - Frontiers in …, 2020 - frontiersin.org
The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of
thousands of individuals worldwide. This highly infectious condition continues to ravage the …

[HTML][HTML] Clinical trials for use of melatonin to fight against COVID-19 are urgently needed

K Kleszczyński, AT Slominski, K Steinbrink, RJ Reiter - Nutrients, 2020 - mdpi.com
The recent pandemic of COVID-19 has already infected millions of individuals and has
resulted in the death of hundreds of thousands worldwide. Based on clinical features …