The relationship between the complement system and autoimmunity appears paradoxical as
both the deficiency and the activation contribute to inducing autoimmune diseases. In these …

Major advances in our understanding of the immunobiology of complement were made
within the past 5 years primarily due to the development of gene‐targeting technology. New …

The complement system is a component of the innate immune system. Its main function was
initially believed to be limited to the recognition and elimination of pathogens through direct …

The preliminary evidence for the involvement of complement in promoting primary humoral
responses dates back over a quarter of a century. However, it is only in the course of the …

The complement system is a major component of innate immunity. Under normal conditions
the contribution of the complement system is beneficial, but when inappropriately activated it …

The complement system is an ancient and evolutionary conserved element of the innate
immune mechanism. It comprises of more than 20 serum proteins most of which are …

The recognition of the association between complete and partial complement (C)
deficiencies and immune complex (IC) mediated diseases, especially SLE, is of clinical and …

The complement system is a central component of innate immunity [1] and is functionally
linked to both the activation and regulatory as well as the effector arms of adaptive immunity …

Complement in inflammatory tissue damage and disease: Trends in Immunology Skip to Main
Content Advertisement Trends in Immunology This journal offers authors two options (open …

Our understanding of the biology of the complement system has undergone a drastic
metamorphosis since its original discovery. This system, which was traditionally primarily …